Peptide Modification Using Inter- and Intramolecular Allenamide-Mediated Conjugate Addition to Develop New Antimicroibials to Combat Difficult-to-Treat Bacterial Infections (129161)
Taeung Na
1
,
Veronika Sander
1
,
Alan Davidson
1
,
Rolland Lin
1
,
Yann Hermant
1
,
Madeleine Hardie Boys
2
,
Daniel Pletzer
2
,
Georgia Campbell
2
,
Scott Ferguson
2
,
Gregory Cook
2
,
Jane Allison
1
,
Catherine Tsai
1
,
Margaret Brimble
1
,
Brian Northrop
3
,
Alan Cameron
1
- University of Auckland, Auckland, New Zealand
- University of Otago, Dunedin, New Zealand
- Wesleyan University, Middletown, USA
Publish consent withheld
- Cameron, A. J.; Harris, P. W. R.; Brimble, M. A. On-Resin Preparation of Allenamidyl Peptides: A Versatile Chemoselective Conjugation and Intramolecular Cyclisation Tool. Angew. Chem. Int. Ed. 2020, 59 (41), 18054–18061
- Na, T.; Sander, V.; Davidson, A. J.; Lin, R.; Hermant, Y. O.; Hardie Boys, M. T.; Pletzer, D.; Campbell, G.; Ferguson, S. A.; Cook, G. M.; Allison, J. R.; Brimble, M. A.; Northrop, B. H.; Cameron, A. Allenamides as a Powerful Tool to Incorporate Diversity: Thia-Michael Lipidation of Semisynthetic Peptides and Access to β-Ketoamides. Angew. Chem. Int. Ed. 2024, 63 (39), e202407764