Friday, 24th October 10th Modern Solid Phase Peptide Synthesis & Its Applications Symposium 2025

• Applications of Cysteine Lipidation “CLipPA” Technology: Drugs, Vaccines and Biomaterials   - Margaret Brimble
• Microcondensate-mediated Antibody Delivery into Cells - Shiroh Futaki

• Tetrahydropyranyl backbone protection for enhanced Fmoc solid-phase peptide synthesis - John A Karas
• Synthesis of glycopeptides by rapid flow-based peptide synthesis - Yuta Maki
• A conduction preheating system to optimize SPPS - Hanson Chang
• Tirzepatide purification with enhanced process economy by YMC-Triart Prep stationary phases and twin-column continuous chromatography (MCSGP-AutoPeak) - Tsuyoshi Watabe
• From linear to macrocyclic Drp1 inhibitors solid phase synthesis and structure activity relationship studies - Nir Qvit
• Fmoc solid-phase synthesis of peptide thioester or its precursor bearing C-terminal tag sequences via γ-substituted proline - Gosuke Hayashi

Precise Peptide Chemistry and its Application to Antibody Conjugates

• Generation of Bispecific Molecules and Their Applications Thereof  - Clarence T. T. Wong
• N-Hydroxy amide as a versatile structural unit for peptide synthesis - Akira Otaka
• Discovery of de novo Macrocycle Inhibitors of Histone Deacetylase 11 - Christian Adam Olsen
• Development of tCAP(N3) for antibody drug conjugate: Affinity peptide-aided site-specific native IgG modification with pH-triggered activatable structure - Yuji Ito

• Next-generation central nervous system delivery: peptide shuttles for systemic transport of antisense oligonucleotide drugs - Fazel Shabanpoor
• Studies on Cell Penetrating Peptide Conjugated Drugs - Vijayalekshmi Sarojini

Superfast protein desulfurization triggered by low-energy visible light - Xiangyu Deng
Mechanically Triggered Protein Desulfurization - Dongyang Han
Peptide ligation mediated by N-aminoacyl-N-hydroxy amino acid - Junya Hayashi
Synthesis of difficult peptide sequence enabled by the use of selenazolidine - Kota Hidaka
Synthesis and modification of monobody variant scaffolds for therapeutic mirror-image monobody - Naoya Iwamoto
Design and Evaluation of ATN-161 Analogues as Fusion Inhibitors Targeting Integrins in SARS-CoV-2 - Naeem-Ul-Haq Khan
One-pot synthesis and construction of bispecific bicyclic peptides for integrin-mediated lysosomal targeted protein degradation - Kwai Man Lau
An Integrated Solubilizing-Tag-Free Strategy for Efficient Chemical Synthesis of Mirror-Image Interleukin-6 - Yanbo Liu
A cancer peptide prodrug activated by an oncolytic virus - Polly Chuanrong Sun
Nucleic Acid Scaffold-assisted Peptide Ligation for Chemical Protein Synthesis - Sae Suzuki
Fmoc-SPPS compatible and physiologically removable protecting group for selenocysteine - Fumika Yoshitomi
An enzyme-cleavable solubilizing-tag facilitates the chemical synthesis of mirror-image proteins - Yupeng Zheng
Synthesis of glycopeptides by rapid flow-based peptide synthesis - Yuta Maki
A conduction preheating system to optimize SPPS - Hanson Chang
Tirzepatide purification with enhanced process economy by YMC-Triart Prep stationary phases and twin-column continuous chromatography (MCSGP-AutoPeak) - Tsuyoshi Watabe
From linear to macrocyclic Drp1 inhibitors solid phase synthesis and structure activity relationship studies - Nir Qvit
Fmoc solid-phase synthesis of peptide thioester or its precursor bearing C-terminal tag sequences via γ-substituted proline - Gosuke Hayashi
Chemical synthesis and functional study of complex glycoproteins - Ping Wang
Structure-guided development of photocaged linear-diubiquitin-Dha as a tunable inhibitor for profiling of linear ubiquitin interactors   - Yiming Li
Electrochemically Enabled Peptide Late-Stage Modifications - Dhanya Karipal Padinjare Veedu
Development of synthetic strategies for peptidomimetics based on haloalkene dipeptide isosteres and their application to cyclic peptides - Takuya Kobayakawa
Developing an Aza-Michael Route to Quaternary Ammonium Compounds and its Application to Antimicrobials - Rolland Lin
Total synthesis of the antifungal and antiviral cyclic lipodepsipeptides verlamelins A and B - Urawadee Rajchakit
Development of a tryptophan-selective chemical modification via thioether-mediated sulfenylation - Akihiro Taguchi
Design of fluorescent and isotopically labelled peptide tracers for the visualization and detection of oxytocin receptor - Predrag Kalaba
Synthesis of α-quaternary diamino diacid building blocks for developing thioether bridge mimics of sactibiotics - Karizza Faith Catenza
Peptide Modification Using Inter- and Intramolecular Allenamide-Mediated Conjugate Addition to Develop New Antimicroibials to Combat Difficult-to-Treat Bacterial Infections - Taeung Na
Preparation of antibody conjugates using tCAP(N₃) for the site-specific modification of native IgG antibodies - Hiroko Kawakami
Developing simplified insulin-like peptide 5 (INSL5) analogues as colon motility regulators - Hongkang Wu
Random antimicrobial peptide mixtures as non-antibiotic antimicrobial agents for cultured meat industry - Idan Yakir
RADIOLABELLED PEPTIDES TARGETING CXCR4 FOR CANCER IMAGING AND TREATMENT - Abdullah Alosaimi
Production of polyethylene glycol-based resin via microfluidic devices for high purity peptide synthesis - Jonghyun Lee
Rational design of short bioactive peptides   - Beatriz G. de la Torre
Effect of deamidation on the fibril formation of β2-microglobulin   - Hironobu Hojo